Many fission cores that stop mitosis, such as cytostatics, such as colchicine and colsemide. Prevents the polymerization of tubulin. As a result, new microtubules do not form. and the finished microtubules are completely disassembled. In this case, the mitotic chromosomes are assembled in the center of the cell. but does not form a metaphase plate but they are arranged in no particular order. Similar results are achieved by actions. of ATP synthesis inhibitor dinitrophenol oligomycin
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